Characterization of Mycobacterium bovis Phagosome

被引：0
|
作者：
Jordao, L. [1 ]
Simoes, M. [1 ]
Bleck, C. [2 ]
Griffiths, G. [2 ]
Anes, E. [1 ]
机构：
[1] Univ Lisbon, Fac Pharm, CPM URIA, P-1600085 Lisbon, Portugal
[2] EMBL, D-69117 Heidelberg, Germany
来源：
MICROSCOPY AND MICROANALYSIS | 2008年 / 14卷
关键词：
D O I：
10.1017/S1431927608089629
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Mycobacterium tuberculosis complex are among the most successful pathogens. Their success resides in the ability to interfere with intracellular traffic avoiding natural pathways of the phagosome maturation. Recently, mycobacteria escape from the phagosome to the cytosol was investigated as an alternative survival strategy. In this context we decided to determine the exact intracellular location of Mycobacterium bovis in different host macrophages and characterize the pathogen intracellular niche for survival. The main goal here was to characterize live vs dead M. bovis spp phagosome in different host macrophages. Macrophages infection, fluorescence and EM procedures were carried out as described previously. © 2008 Microscopy Society of America.
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页码：124 / 125
页数：2
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