SYNTHESIS OF MACROCYCLES WITH ONE AND MORE ent- BEYERANE SKELETONS BASED ON THE DITERPENOID ISOSTEVIOL

被引：9
|
作者：
Garifullin, B. F. [1 ]
Strobykina, I. Yu. [1 ]
Lodochnikova, O. A. [1 ]
Musin, R. Z. [1 ]
Gubaidullin, A. T. [1 ]
Kataev, V. E. [1 ]
机构：
[1] Russian Acad Sci, Kazan Sci Ctr, AE Arbuzov Organ & Phys Chem Inst, Kazan 420088, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2011年 / 47卷 / 03期
关键词：
macrocycles; diterpenoids; beyeranes; isosteviol; PEPTIDE SIDE-CHAIN; JATROPHANE DITERPENES; BIOLOGICAL-ACTIVITIES; DOCETAXEL ANALOGS; DISCOVERY; TAXOIDS;
D O I：
10.1007/s10600-011-9949-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Macrocycles with one and more ent-beyerane skeletons were prepared by the reaction of 16,19-dihydroxyent-beyerane with several dibasic carboxylic acid chlorides. The structures of the synthesized compounds, namely, the number of ent-beyerane skeletons in the macrocycle, depended on the length of the polymethylene chain in the acid chloride. The molecular structures of two of the synthesized macrocycles were established by x-ray crystal structures.
引用
收藏
页码：422 / 427
页数：6
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