Endocrine complications in long-term survivors of childhood cancers

被引：140
|
作者：
Chemaitilly, Wassim [1 ]
Sklar, Charles A. [2 ]
机构：
[1] UPMC, Childrens Hosp Pittsburgh, Dept Pediat, Div Endocrinol, Pittsburgh, PA 15224 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA
来源：
ENDOCRINE-RELATED CANCER | 2010年 / 17卷 / 03期
关键词：
ACUTE LYMPHOBLASTIC-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; TOTAL-BODY IRRADIATION; GROWTH-HORMONE TREATMENT; FUNCTION FOLLOWING CHEMOTHERAPY; IMPAIRED GLUCOSE-TOLERANCE; STEM-CELL TRANSPLANTATION; YOUNG-ADULT SURVIVORS; OVARIAN-FUNCTION; FINAL HEIGHT;
D O I：
10.1677/ERC-10-0002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Endocrine disturbances are among the most frequently reported complications in childhood cancer survivors, affecting between 20 and 50% of individuals who survive into adulthood. Most endocrine complications are the result of prior cancer treatments, especially radiotherapy. The objective of the present review is to discuss the main endocrine complications observed in this population, including disorders of the hypothalamic-pituitary axis, disorders of pubertal development, thyroid dysfunction, gonadal dysfunction, decreased bone mineral density, obesity, and alterations in glucose metabolism with a special focus on recent findings reported from the Childhood Cancer Survivor Study. Endocrine-Related Cancer (2010) 17 R141-R159
引用
收藏
页码：R141 / R159
页数：19
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