Velocity distributions in a micromixer measured by NMR imaging

被引:6
|
作者
Ahola, Susanna [1 ]
Telkki, Ville-Veikko [1 ]
Stapf, Siegfried [1 ]
机构
[1] Univ Oulu, Dept Phys Sci Univ, NMR Res Grp, Oulu 90014, Finland
基金
芬兰科学院;
关键词
ON-A-CHIP; MICROFLUIDIC DEVICES; SINGLE-MOLECULE; FLOW; TECHNOLOGIES; SYSTEMS; GROWTH;
D O I
10.1039/c2lc21214e
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Velocity distributions (so-called propagators) with two-dimensional spatial resolution inside a chemical micromixer were measured by pulsed-field-gradient spin-echo (PGSE) nuclear magnetic resonance (NMR). A surface coil matching the volume of interest was built to enhance the signal-to-noise ratio. This enabled the acquisition of velocity maps with a very high spatial resolution of 29 mu m x 39 mu m. The measured propagators are compared with theoretical distributions and a good agreement is found. The results show that the propagator data provide much richer information about flow behaviour than conventional NMR velocity imaging and the information is essential for understanding the performance of a micromixer. It reveals, for example, deviations in the shape and size of the channel structures and multicomponent flow velocity distribution of overlapping channels. Propagator data efficiently compensate lost information caused by insufficient 3D resolution in conventional velocity imaging.
引用
收藏
页码:1823 / 1830
页数:8
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