Industrial scale-up of countercurrent chromatography

被引：23

作者：

Sutherland, IA ^{[1
]}

Booth, AJ

Brown, L

Kemp, B

Kidwell, H

Games, D

Graham, AS

Guillon, GG

Hawes, D

Hayes, M

Janaway, L

Lye, GJ

Massey, P

Preston, C

Shering, P

Shoulder, T

Strawson, C

Wood, P

机构：

[1] Brunel Univ, Brunel Inst Bioengn, Uxbridge UB8 3PH, Middx, England

[2] UCL Adv Ctr Biochem Engn, Dept Biochem Engn, London WC1E 7JE, England

[3] AECS, Bridgend CF31 4XZ, Mid Glamorgan, Wales

[4] Zeneca Agrochem, Bracknell, Berks, England

[5] Univ Coll Swansea, Dept Chem, Swansea SA2 8PP, W Glam, Wales

[6] AstraZeneca, Macclesfield SK10 2NA, Cheshire, England

[7] Univ Pau, ENSGTI, F-64000 Pau, France

[8] Glaxo Wellcome, Med Res Ctr, Bioproc Unit, Stevenage, Herts, England

[9] Glaxo Wellcome Operat, Ulverston LA12 9DR, Cumbria, England

[10] Zeneca Pharmaceut, Manchester, Lancs, England

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2001年 / 24卷 / 11-12期

关键词：

D O I：

10.1081/JLC-100104362

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The hydrodynamic, engineering, and chromatographic variables affecting scale-up of countercurrent chromatography (CCC) are examined. The predictable and linear scale-up from the current laboratory scale technology to industrial process scale, capable of kgm/month in the first phase, is demonstrated. Continued research will prepare the way for a new generation of tonne/annum capacity high throughput, high resolution CCC machines for pilot and plant scale separations of a range of bioprocess products.

引用

页码：1533 / 1553

页数：21

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