Atrial fibrillation, stroke and dementia in the very old: A population-based study

被引：59
|
作者：
Marengoni, Alessandra [1 ,2 ]
Qiu, Chengxuan [2 ]
Winblad, Bengt [2 ]
Fratiglioni, Laura [2 ,3 ]
机构：
[1] Univ Brescia, Spedali Civili, Geriatr Unit, Piazzale Spedali Civili 1,Dept Med & Surg Sci, I-25121 Brescia, Italy
[2] Karolinska Inst, Aging Res Ctr, NVS Dept, SE-11330 Stockholm, Sweden
[3] Stockholm Gerontol Res Ctr, SE-11330 Stockholm, Sweden
来源：
NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 07期
基金：
瑞典研究理事会;
关键词：
Atrial fibrillation; Stroke; Dementia; Alzheimer's disease; Population-based study;
D O I：
10.1016/j.neurobiolaging.2009.08.002
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
We explored the association of chronic AF with stroke, dementia and Alzheimer's disease (AD) among community-dwelling elderly people. The study population consisted of 685 individuals from Stockholm (The Kungsholmen Project) who were aged 78 years and were free of dementia and clinical stroke. During the 6-year follow-up, 170 subjects developed dementia, and 86 persons experienced first-ever stroke. The incidence rate (per 1000 person-years) of dementia, AD and first-ever stroke was 72.3, 52.2, and 52.2 in persons with AF and 63.8, 54.6 and 30.6 in those without AF, respectively. AF was associated with the hazard ratio of 1.8 (95% CI, 1.0-3.4) for first-ever stroke, but not significantly associated with dementia or AD. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：1336 / 1337
页数：2
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