Integration of the PRB and p53 cell cycle control pathways

被引：16

作者：

Stewart, CL

Soria, AM

Hamel, PA

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

[2] Ctr Genet Engn & Biotechnol, Havana, Cuba

来源：

JOURNAL OF NEURO-ONCOLOGY | 2001年 / 51卷 / 03期

关键词：

pRB; p53; cell cycle; cell growth; cell death; tumor suppressor gene;

D O I：

10.1023/A:1010615822317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Two fundamental molecular pathways, the pRB and p53 pathways, regulate cell growth and cell death. The importance of these pathways in cellular growth control is underscored by the observation that members of these pathways are found mutated in all human cancer. These two pathways have typically been studied and described independently. However, as we discuss here, recent data have revealed an intimate molecular and genetic interaction between the p53 and pRB pathways.

引用

页码：183 / 204

页数：22

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