Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants

被引：30
|
作者：
Vesoulis, Zachary A. [1 ]
Bank, Rachel L. [1 ]
Lake, Doug [2 ]
Wallman-Stokes, Aaron [3 ]
Sahni, Rakesh [3 ]
Moorman, J. Randall [2 ]
Isler, Joseph R. [3 ]
Fairchild, Karen D. [4 ]
Mathur, Amit M. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Pediat, Div Newborn Med, St Louis, MO 63110 USA
[2] Univ Virginia, Dept Med, Charlottesville, VA USA
[3] Columbia Univ, Dept Pediat, New York, NY 10027 USA
[4] Univ Virginia, Dept Pediat, Charlottesville, VA USA
来源：
JOURNAL OF PERINATOLOGY | 2019年 / 39卷 / 01期
基金：
美国国家卫生研究院;
关键词：
BIRTH-WEIGHT INFANTS; CEREBRAL-BLOOD-FLOW; OXYGEN-SATURATION; GERMINAL MATRIX; INTRAVENTRICULAR HEMORRHAGE; DEATH; AUTOREGULATION; VALIDATION; DISABILITY; OUTCOMES;
D O I：
10.1038/s41372-018-0236-2
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objectives: The objective of this study was to define the association between the burden of severe hypoxemia (SpO(2) <= 70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO(2) recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO(2) <= 70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results: A total of 163.3 million valid SpO(2) data points were collected from 645 infants with mean EGA = 27.7 +/- 2.6 weeks, BW = 1005 +/- 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.
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收藏
页码：48 / 53
页数：6
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