Trimethylsilylcyanation of aromatic aldehydes catalyzed by BINOL-Li salt

被引：0

作者：

Liu, DX

Wang, Q

Zhang, LC

Da, CS

Wang, R ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Life Sci, Dept Biochem & Mol Biol, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2001年 / 22卷 / 04期

关键词：

R-(+)-1,1 '-2-bisnaphthol; enantioselective synthesis; cyanotrimethylsilane; aromatic cyanohydrins;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of aromatic cyanohydrins and their O-silyl ethers have been synthesized by trimethylsilylcyanation of aromatic aldehydes using a catalyst generated in situ from optically active R-(+)-1,1 ' -2-bisnaphthol with n-butyl lithium. Mandelonitrile was prepared in an isolated yield 70% with more than e.e. = 60%. The effect of solvents and the amount of catalyst on enantioselectivity was also investigated.

引用

页码：601 / 602

页数：2

共 8 条

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