Role of Substrate Microstructure on Osteogenic Differentiation of Mesenchymal Stem Cells

被引：2
|
作者：
Jabbari, Esmaiel
机构：
来源：
2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2010年
关键词：
MARROW STROMAL CELLS; BONE; HYDROGEL; MACROMER; RGD;
D O I：
10.1109/IEMBS.2010.5627489
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The objective of this work was to investigate the effect of substrate microstructure (planar versus microtubular geometry) on the extent of osteogenic differentiation of bone mesenchymal stem (BMS) cells. For laminated sheets, the BMS cell suspension was seeded on the sheets and cultured in complete osteogenic media. For laminated microtubes, the BMS cell suspension was injected in the tubes and allowed to incubate in osteogenic media. BMS cells cultured in osteonmimetic microtubes had drastically higher ALPase activity and calcium content, compared to laminated sheets. The data demonstrate that the 3D environment of the microtubes profoundly affects osteogenic differentiation of the BMS cells, compared to the 2D laminated sheets.
引用
收藏
页码：3543 / 3545
页数：3
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