Nonsteroidal anti-inflammatory drugs for retinal neurodegenerative diseases

被引：0

作者：

Chen, Chen ^{[1
]}

Wang, Chenguang ^{[1
]}

Zhou, Xuebin ^{[1
]}

Xu, Lingxian ^{[1
]}

Chen, Han ^{[1
]}

Qian, Kun ^{[1
]}

Jia, Bo ^{[1
]}

Su, Guanfang ^{[1
]}

Fu, Jinling ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Ophthalmol, 4026 Yatai St, Changchun, Jilin 130022, Peoples R China

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2021年 / 156卷

关键词：

NSAIDs; Retinal neurodegenerative diseases; Age-related macular degeneration; Diabetic retinopathy; ENDOTHELIAL GROWTH-FACTOR; INDUCED OCULAR INFLAMMATION; PROSTAGLANDIN E-2 LEVELS; DIABETIC MACULAR EDEMA; CHOROIDAL NEOVASCULARIZATION; INTRAOCULAR-PRESSURE; INTRAVITREAL DICLOFENAC; BROMFENAC; 0.09-PERCENT; KETOROLAC TROMETHAMINE; TOPICAL NEPAFENAC;

D O I：

10.1016/j.prostaglins.2021.106578

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most common prescription drugs for inflammation, and topical NSAIDs are often used in ophthalmology to reduce pain, photophobia, inflammation, and edema. In recent years, many published reports have found that NSAIDs play an important role in the treatment of retinal neurodegenerative diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, pathological myopia, and retinitis pigmentosa (RP). The aim of the current review is to provide an overview of the role of various NSAIDs in the treatment of retinal neurodegenerative diseases and the corresponding mechanisms of action. This review highlighted that the topical application of NSAIDs for the treatment of retinal degenerative diseases has been studied to a remarkable extent and that its beneficial effects in many diseases have been proven. In the future, prospective studies with large study populations are required to extend these effects to clinical settings.

引用

页数：7

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