Manganese superoxide dismutase vs p53 Regulation of mitochondrial ROS

被引：52

作者：

Holley, Aaron K. ^{[1
]}

Dhar, Sanjit Kumar ^{[1
]}

St Clair, Daret K. ^{[1
]}

机构：

[1] Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA

来源：

MITOCHONDRION | 2010年 / 10卷 / 06期

关键词：

Mitochondria; Manganese superoxide dismutase; p53; Reactive oxygen species; WILD-TYPE P53; NF-KAPPA-B; HYDROGEN-PEROXIDE PRODUCTION; CELL-CYCLE PROGRESSION; CENTRAL-NERVOUS-SYSTEM; TUMOR-SUPPRESSOR P53; OXYGEN-FREE RADICALS; DNA-BINDING ACTIVITY; REACTIVE OXYGEN; OXIDATIVE STRESS;

D O I：

10.1016/j.mito.2010.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Coordination of mitochondrial and nuclear activities is vital for cellular homeostasis and many signaling molecules and transcription factors are regulated by mitochondria derived reactive oxygen species (ROS) to carry out this interorganellar communication The tumor suppressor p53 regulates myriad cellular functions through transcription-dependent and independent mechanisms at both the nucleus and mitochondria p53 affect mitochondria! ROS production in part by regulating the expression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) Recent evidence suggests mitochondrial regulation of p53 activity through mechanisms that affect ROS production and a breakdown of communication amongst mitochondria p53 and the nucleus can have broad implications in disease development (C) 2010 Elsevier B V and Mitochondria Research Society All rights reserved

引用

页码：649 / 661

页数：13

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