In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy

被引：14
|
作者：
Hamzian, Nima [1 ]
Hashemi, Maryam [2 ]
Ghorbani, Mahdi [3 ]
Aledavood, Seyed Amir [4 ]
Ramezani, Mohammad [5 ,6 ]
Toossi, Mohammad Hossein Bahreyni [7 ]
机构：
[1] Shahid Sadoughi Univ Med Sci, Fac Med, Dept Med Phys, Yazd, Iran
[2] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Inst Pharmaceut Technol, Mashhad, Razavi Khorasan, Iran
[3] Shahid Beheshti Univ Med Sci, Fac Med, Dept Biomed Engn & Med Phys, Tehran, Iran
[4] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Razavi Khorasan, Iran
[5] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Inst Pharmaceut Technol, Mashhad, Razavi Khorasan, Iran
[6] Mashhad Univ Med Sci, Dept Pharmaceut Biotechnol, Sch Pharm, Mashhad, Razavi Khorasan, Iran
[7] Mashhad Univ Med Sci, Med Phys Res Ctr, Fac Med, Mashhad, Razavi Khorasan, Iran
来源：
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2019年 / 18卷 / 04期
基金：
美国国家科学基金会;
关键词：
Multifunctional drug delivery system; SPION-PLGA; Gemcitabine; Radiotherapy; Radiosensitizer; CANCER-CELLS; DELIVERY; FE3O4; VIVO;
D O I：
10.22037/ijpr.2019.14050.12131
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparlicles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system. The physicochemical characteristics of the nanoparticles (NPs) were studied. The dose enhancement ratio (DER) of various treatment groups was calculated and compared using human breast cancer cell line (MCF-7). The DER for PLGA-SPION-Gem was the highest at 1 Gy(60)Co (3.18). Cumulative effect from simultaneous use of two radiosensitizer (Gem and SPIONs) was observed. Thus, we have successfully developed PLGA NPs loaded with gemcitabine and SPIONas a radiosensitizersystem which potentially could be used in radiotherapy.
引用
收藏
页码：1694 / 1703
页数：10
相关论文
共 50 条
  • [1] Preparation, Optimization and Toxicity Evaluation of (SPION-PLGA) ± PEG Nanoparticles Loaded with Gemcitabine as a Multifunctional Nanoparticle for Therapeutic and Diagnostic Applications
    Hamzian, Nima
    Hashemi, Maryam
    Ghorbani, Mahdi
    Ramezani, Mohammad
    Toosi, Mohammad Hossein Bahreyni
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 16 (01): : 8 - 21
  • [2] Smart PLGA nanoparticles loaded with Quercetin: Cellular uptake and in-vitro anticancer study
    Halder, Asim
    Mukherjee, Pritha
    Ghosh, Subarna
    Mandal, Saptarshi
    Chatterji, Urmi
    Mukherjee, Amp
    MATERIALS TODAY-PROCEEDINGS, 2018, 5 (03) : 9698 - 9705
  • [3] Breast radiotherapy with kilovoltage photons and gold nanoparticles as radiosensitizer: An in vitro study
    Tudda, Alessia
    Donzelli, Elisabetta
    Nicolini, Gabriella
    Semperboni, Sara
    Bossi, Mario
    Cavaletti, Guido
    Castriconi, Roberta
    Mangili, Paola
    Del Vecchio, Antonella
    Sarno, Antonio
    Mettivier, Giovanni
    Russo, Paolo
    MEDICAL PHYSICS, 2022, 49 (01) : 568 - 578
  • [4] THE STUDY OF SYNTETIC PEPTIDE LOADED PLGA NANOPARTICLES CYTOTOXICITY IN VITRO
    Derman, Serap
    Akdeste, Zeynep Mustafaeva
    Ates, Sezen Canim
    Mansuroglu, Banu
    Kizilbey, Kadriye
    Bagirova, Melahat
    Allahverdiyev, Adil
    FRESENIUS ENVIRONMENTAL BULLETIN, 2017, 26 (2A): : 1646 - 1653
  • [5] In vitro kinetic release study of terminalia arjuna loaded PLGA nanoparticles
    Kumari, Vinod
    Sangal, Aditi
    Mehta, Rajeev
    Trends in Biomaterials and Artificial Organs, 2021, 35 (01): : 10 - 14
  • [6] Effect of Peptide-Lipid Conjugates Loaded PLGA Nanoparticles Against Cancer Cells In-Vitro
    Koyuncu, Reyhan
    Duruksu, Gokhan
    Ozcelik, Beraat
    Mert, Serap
    Yazir, Yusufhan
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2023, 19 (08) : 1321 - 1336
  • [7] Fabrication and in-vitro Evaluation of Ketotifen Fumarate-loaded PLGA Nanoparticles as a Sustained Delivery System
    Soltani, Saieede
    Zakeri-Milani, Parvin
    Barzegar-Jalali, Mohammad
    Jelvehgari, Mitra
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2017, 16 (01): : 22 - 34
  • [8] In-vitro evaluation of paclitaxel-loaded MPEG-PLGA nanoparticles on laryngeal cancer cells
    Gao, ChunLi
    Pan, Jun
    Lu, WeiYue
    Zhang, Ming
    Zhou, Liang
    Tian, Jie
    ANTI-CANCER DRUGS, 2009, 20 (09) : 807 - 814
  • [9] In-Vitro and In-Vivo Study of Indomethacin Loaded Gelatin Nanoparticles
    Kumar, Rakesh
    Nagarwal, Ramesh C.
    Dhanawat, Meenakshi
    Pandit, Jayanta Kumar
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2011, 7 (03) : 325 - 333
  • [10] Development of bicalutamide-loaded PLGA nanoparticles: preparation, characterization and in-vitro evaluation for the treatment of prostate cancer
    Ray, Sayantan
    Ghosh, Suparna
    Mandal, Supratim
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2017, 45 (05) : 944 - 954
12345