Synthesis of Aryl Ketoamides via Aryne Insertion into lmides

被引：41

作者：

Wright, Austin C. ^{[1
]}

Haley, Christopher K. ^{[1
]}

Lapointe, Guillaume ^{[1
]}

Stoltz, Brian M. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Warren & Katharine Schlinger Lab Chem & Chem Engn, 1200 East Calif Blvd,MC 101-20, Pasadena, CA 91125 USA

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 12期

基金：

瑞士国家科学基金会; 美国国家科学基金会;

关键词：

SKELETONS;

D O I：

10.1021/acs.orglett.6b00994

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An insertion of arenes into both imides and anhydrides via reactive aryne intermediates presented. The reaction is performed under exceptionally mild conditions, and the corresponding ketoamide products are amenable to derivatization to deliver a variety of synthetically useful motifs such:as quinolones, indoles, and ketoanilines.

引用

页码：2793 / 2795

页数：3

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