Correlation between acute phase-related expression of C/EBPβ and transcriptional regulation of the haptoglobin gene during rat liver development

被引：0
|
作者：
Mihailovic, M [1 ]
Petrovic, M [1 ]
Bogojevic, D [1 ]
机构：
[1] Inst Biol Res, YU-11060 Belgrade, Yugoslavia
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 2000年 / 19卷 / 03期
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hepatic 35 kD nucleoprotein participates in transcriptional regulation of the haptoglobin gene during the development of rat liver. The same molecular mass and trans-acting role of the above protein as the active isoform of C/EBP beta transcription factor, made homology between them possible. We could detect C/EBP beta in control hepatic nuclear extracts not earlier than in the second week after the birth. However, the acute-phase reaction induced the expression of 35 kD-C/EBP beta at day 7 of postnatal development suggesting that the above trans-active nucleoprotein displays the structural and functional characteristics of C/EBP beta isoform from that day on.
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页码：317 / 321
页数：5
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