ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case-control studies

Polymorphisms in the elaC homolog-2 (ELAC2)/HPC2 gene have been hypothesized to alter the risk of prostate cancer. However, the results of the related published studies remained conflicting. We performed a meta-analysis of 18 studies evaluating the association between ELAC2 Ser217Leu and Ala541Thr polymorphisms and prostate cancer risk. Overall, ELAC2 Leu217 allele was associated with increased prostate cancer risk as compared with the Ser217 allele (odds ratio (OR) = 1.13, 95% confidence interval (CI): 1.03-1.24, P = 0.019 for heterogeneity), as well as in the heterozygote comparison (OR = 1.21, 95% CI: 1.07-1.36, P = 0.034 for heterogeneity) and the dominant genetic model (OR - 1.20, 95% CI: 1.07-1.35, P - 0.025 for heterogeneity). Furthermore, the ELAC2 Thr541 allele was associated with increased prostate cancer risk as compared with the Ala541 allele (OR = 1.22, 95% CI: 1.00-0.48, P = 0.131 for heterogeneity). In the stratified analyses for Ser217Leu polymorphism, there was significantly increased prostate cancer risk in Asian and Caucasian populations, and studies using sporadic and familial prostate cancer cases. Similar result was found in the Asian population in the stratified analyses for Ala541Thr polymorphism. This meta-analysis showed evidence that ELAC2 Ser217Leu and Ala541Thr polymorphisms were associated with prostate cancer risk, and might be low-penetrance susceptibility markers of prostate cancer. Prostate Cancer and Prostatic Diseases (2010) 13, 270-277; doi:10.1038/pcan.2010.6; published online 16 March 2010