Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents

被引：37

作者：

Xu, Bo ^{[1
]}

Kong, Xiao-Le ^{[2
]}

Zhou, Tao ^{[1
]}

Qiu, Di-Hong ^{[3
]}

Chen, Yu-Lin ^{[2
]}

Liu, Mu-Song ^{[4
]}

Yang, Rong-Hua ^{[1
]}

Hider, Robert C. ^{[2
]}

机构：

[1] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Hangzhou 310012, Zhejiang, Peoples R China

[2] Kings Coll London, Div Pharmaceut Sci, London SE1 9NH, England

[3] Ningbo Univ, Fac Life Sci & Biotechnol, Ningbo 315211, Zhejiang, Peoples R China

[4] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Iron chelator; 3-Hydroxypyridin-4-one; Hexadentate; Antimicrobial activity; IRON CHELATORS; PHYSICOCHEMICAL PROPERTIES; BIOLOGICAL EVALUATION; BACTERIAL-GROWTH; INHIBITION; DESIGN; THALASSEMIA; THERAPY; ICL670;

D O I：

10.1016/j.bmcl.2011.08.097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Iron is a critical element for the survival of bacteria. We have designed and synthesized two novel 3-hydroxypyridin-4-one hexadentate ligands with high affinity for iron(III), which disrupt bacterial iron absorption. Biological studies demonstrate that these two chelators have significant inhibitory effect against both Gram-positive and Gram-negative bacteria, and therefore have potential as antimicrobial agents. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6376 / 6380

页数：5

共 50 条

[1] Design and characterisation of novel hexadentate 3-hydroxypyridin-4-one ligands
Piyamongkol, S
Zhou, T
Liu, ZD
Khodr, HH
Hider, RC
TETRAHEDRON LETTERS, 2005, 46 (08) : 1333 - 1336
[2] NOVEL 3-HYDROXYPYRIDIN-4-ONE HEXADENTATE LIGAND-BASED POLYMERIC IRON CHELATOR: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION
Zhou, Tao
Zhou, Yingjun
Kong, Xiaole
Li, Junpei
Ma, Yongmin
Hider, Robert
AMERICAN JOURNAL OF HEMATOLOGY, 2016, 91 (03) : E22 - E22
[3] Novel 3-hydroxypyridin-4-one hexadentate ligand-based polymeric iron chelator: synthesis, characterization and antimicrobial evaluation
Zhou, Ying-Jun
Kong, Xiao-Le
Li, Jun-Pei
Ma, Yong-Min
Hider, Robert C.
Zhou, Tao
MEDCHEMCOMM, 2015, 6 (09) : 1620 - 1625
[4] Synthesis and iron(III)-chelating properties of novel 3-hydroxypyridin-4-one hexadentate ligand-containing copolymers
Zhou, Tao
Le Kong, Xiao
Liu, Zu Dong
Liu, Ding Yong
Hider, Robert C.
BIOMACROMOLECULES, 2008, 9 (05) : 1372 - 1380
[5] Synthesis of polymers containing 3-hydroxypyridin-4-one bidentate ligands for treatment of iron overload
Saghaie, Lotfollah
Liu, Dy
Hider, Robert C.
RESEARCH IN PHARMACEUTICAL SCIENCES, 2015, 10 (04) : 364 - 377
[6] DIBI, a 3-hydroxypyridin-4-one chelator iron-binding polymer with enhanced antimicrobial activity
Trisha, M.
Ang, C.
Gumbau-Brisa, Roger
Allan, David S.
McDonald, Robert
Ferguson, Michael J.
Holbein, Bruce E.
Bierenstiel, Matthias
MEDCHEMCOMM, 2018, 9 (07) : 1206 - 1212
[7] High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization
Zhou, T
Liu, ZD
Neubert, H
Le Kong, X
Ma, YM
Hider, RC
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (22) : 5007 - 5011
[8] Design, Synthesis, and Antimicrobial Evaluation of Hexadentate Hydroxypyridinones with High Iron(III) Affinity
Zhang, Ming-Xia
Zhu, Chun-Feng
Zhou, Ying-Jun
Kong, Xiao-Le
Hider, Robert C.
Zhou, Tao
CHEMICAL BIOLOGY & DRUG DESIGN, 2014, 84 (06) : 659 - 668
[9] EFFECT OF IRON OVERLOAD ON THE METABOLISM AND URINARY RECOVERY OF 3-HYDROXYPYRIDIN-4-ONE CHELATING-AGENTS IN THE RAT
CHOUDHURY, R
SINGH, S
DRUG METABOLISM AND DISPOSITION, 1995, 23 (03) : 314 - 320
[10] ELECTROCHEMICAL OXIDATION OF SOME THERAPEUTIC 3-HYDROXYPYRIDIN-4-ONE IRON CHELATORS
ELJAMMAL, A
TEMPLETON, DM
ELECTROCHIMICA ACTA, 1993, 38 (15) : 2223 - 2230

← 1 2 3 4 5 →