Tuberculosis Drug Development Ensuring People Living with HIV Are Not Left Behind

被引：11

作者：

Luetkemeyer, Anne F. ^{[1
]}

Getahun, Haileyesus ^{[2
]}

Chamie, Gabriel ^{[1
]}

Lienhardt, Christian

Havlir, Diane V. ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco Gen Hosp, Div HIV AIDS, San Francisco, CA 94110 USA

[2] WHO, Stop TB Dept, CH-1211 Geneva, Switzerland

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2011年 / 184卷 / 10期

基金：

美国国家卫生研究院;

关键词：

tuberculosis; HIV/AIDS; drug development; MULTIDRUG-RESISTANT TUBERCULOSIS; ACQUIRED RIFAMYCIN RESISTANCE; EARLY BACTERICIDAL ACTIVITY; PULMONARY TUBERCULOSIS; DIARYLQUINOLINE TMC207; ANTIRETROVIRAL THERAPY; PHASE-II; PHARMACOKINETICS; MOXIFLOXACIN; RIFAMPIN;

D O I：

10.1164/rccm.201106-0995PP

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Anunprecedented number of new tuberculosis (TB) medications are currently in development, and there will be great pressure to deploy these new drugs among all populations after their efficacy is demonstrated. People living with HIV experience a large burden of TB and have a particularly pressing need for TB treatments that are shorter and less toxic. In addition, all people living with HIV now require antiretroviral therapy during TB treatment. A roadmap of the research, programmatic, and regulatory considerations includes the following: (1) inclusion of people living with HIV early in clinical trials for treatment and prevention using new TB medications, (2) prioritization of key studies of HIV-TB drug interactions and interactions between new TB agents, and (3) optimization of clinical trial infrastructure, laboratory capacity, and drug susceptibility testing.

引用

页码：1107 / 1113

页数：7

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