Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels

被引:4
|
作者
Mansouri, Vahid [1 ]
Razzaghi, Mohammadreza [2 ]
Rostami-Nejad, Mohammad [3 ]
Rezaei-Tavirani, Majid [4 ]
Heidari, Mohammad Hossein [1 ]
Safari, Saeed [5 ]
Arjmand, Babak [6 ]
Rezaei-Tavirani, Mostafa [1 ]
Zali, Alireza [7 ]
Hamdieh, Mostafa [8 ]
机构
[1] Shahid Beheshti Univ Med Sci, Fac Paramed Sci, Prote Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Laser Applicat Med Sci Res Ctr, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Gastroenterol & Liver Dis Res Ctr, Res Inst Gastroenterol & Liver Dis, Tehran, Iran
[4] Iran Univ Med Sci, Firoozabadi Hosp, Fac Med, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Dept Emergency Med, Tehran, Iran
[6] Univ Tehran Med Sci, Cell Therapy & Regenerat Med Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran
[7] Shahid Beheshti Univ Med Sci, Funct Neurosurg Res Ctr, Tehran, Iran
[8] Shahid Beheshti Univ Med Sci, Taleghani Hosp, Fac Med, Dept Psychosomat, Tehran, Iran
关键词
Photobiomodulation therapy; Retina; Gene expression; Protein-protein interaction network; Rat; LASER THERAPY; C-MYC; SKIN;
D O I
10.34172/jlms.2020.47
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Introduction: Photobiomodulation (PBM) is known as low-level laser (or light) therapy and is applied in different fields of medicine. However, it is required that its molecular and cellular mechanism be investigated. This study aims to assess the neuroprotective properties of PBM in the rat retina. Methods: GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment. Results: The 78 produced DEGs by light-damage in the rat retina were protected via PBM pretreatment action. Among these determined DEGs, 53 individuals were included in the main connected component of the constructed protein-protein interaction (PPI) network. Ccl2, Icam1, Cxcl10, Timp1, and Fos were determined as hub nodes. Eight clusters including 26 regulated biochemical pathways by PBM pretreatment were identified. The critical DEGs based on the action maps were introduced. Conclusion: The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation.
引用
收藏
页码:280 / 286
页数:7
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