ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

被引：37
|
作者：
Yue, Hanxun [1 ,2 ,3 ]
Hu, Zenan [2 ,3 ]
Hu, Rui [1 ,4 ]
Guo, Zeying [5 ]
Zheng, Ya [1 ,2 ]
Wang, Yuping [2 ,3 ]
Zhou, Yongning [2 ,3 ]
机构：
[1] Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China
[2] Lanzhou Univ, Dept Gastroenterol, Hosp 1, Lanzhou, Peoples R China
[3] Lanzhou Univ, Key Lab Gastrointestinal Dis Gansu Prov, Hosp 1, Lanzhou, Peoples R China
[4] Lanzhou Univ, Key Lab Reprod Med & Embryo Gansu Prov, Hosp 1, Lanzhou, Peoples R China
[5] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
aldehyde dehydrogenases; cancer stem cell; carcinogenesis; drug resistance; hepatocellular carcinoma; ALDEHYDE DEHYDROGENASE 1A1; STEM-CELL MARKERS; BREAST-CANCER; DOWN-REGULATION; EXPRESSION; PROGNOSIS; CHEMOTHERAPY; ASSOCIATION; METASTASIS; DECREASES;
D O I：
10.3389/fonc.2022.918778
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies and found that ALDH1A1 could induce cancers via the maintenance of cancer stem cell properties, modification of metabolism, promotion of DNA repair. ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often causes chemotherapy failure. Currently, ALDH1A1-targeted therapy is widely used in cancer treatment, but the mechanism by which ALDH1A1 regulates cancer development is not fully understood. This review will provide insight into the status of ALDH1A1 research and new viewpoint for cancer therapy.
引用
收藏
页数：11
相关论文
共 50 条
  • [1] Targeting ALDH1A1 and stemness regulatory networks in ovarian cancer
    Muralikrishnan, Vaishnavi
    Fang, Fang
    Given, Tyler C.
    Podicheti, Ram
    Rusch, Douglas B.
    Hurley, Thomas D.
    Nephew, Kenneth P.
    CANCER RESEARCH, 2022, 82 (12)
  • [2] How to conjugate the stemness marker ALDH1A1 with tumor angiogenesis, progression, and drug resistance
    Ciccone, Valerio
    Morbidelli, Lucia
    Ziche, Marina
    Donnini, Sandra
    CANCER DRUG RESISTANCE, 2020, 3 (01) : 26 - 37
  • [3] ALDH1A1 Expression Is Enriched in Early-Onset Colorectal Cancers
    Venugopal, Anand
    Koi, Minoru
    Choi, Chan
    Kim, Hyeong-Rok
    Speliotes, Elizabeth K.
    Carethers, John M.
    GASTROENTEROLOGY, 2022, 163 (06) : 1679 - +
  • [4] ALDH1A1 and ALDH3A1 expression in lung cancers: Correlation with histologic type and potential precursors
    Patel, Miten
    Lu, Li
    Zander, Dani S.
    Sreerama, Lakshmaiah
    Coco, Dominique
    Moreb, Jan S.
    LUNG CANCER, 2008, 59 (03) : 340 - 349
  • [5] Raloxifene and bazedoxifene as selective ALDH1A1 inhibitors to ameliorate cyclophosphamide resistance: A drug repurposing approach
    Narendra, Gera
    Raju, Baddipadige
    Verma, Himanshu
    Kumar, Manoj
    Jain, Subheet Kumar
    Tung, Gurleen Kaur
    Thakur, Shubham
    Kaur, Rasdeep
    Kaur, Satwinderjeet
    Sapra, Bharti
    Singh, Pankaj Kumar
    Silakari, Om
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 242
  • [6] Role and mechanism of ALDH1A1 expression in the development of gastric cancer
    Guo, Fei
    Gao, Xiao-Bin
    Sun, Guang-Yuan
    Nie, Shuang-Fa
    Zhang, Xiao-Yang
    Qu, Ming
    Wu, Xue-Liang
    Xue, Jun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 9 (06): : 10201 - 10210
  • [7] EARLY-ONSET COLORECTAL CANCERS MANIFEST INCREASED ALDH1A1 EXPRESSION
    Venugopal, Anand
    Koi, Minoru
    Stetson, L. C.
    Speliotes, Elizabeth
    Carethers, John M.
    GASTROENTEROLOGY, 2022, 162 (07) : S221 - S221
  • [8] Clinicopathological significance of ALDH1A1 in lung, colorectal, and breast cancers: a meta-analysis
    Zhou, Yang
    Wang, Yixun
    Ju, Xinxin
    Lan, Jiaojiao
    Zou, Hong
    Li, Shugang
    Qi, Yan
    Jia, Wei
    Hu, Jianming
    Liang, Weihua
    Zhang, Wenjie
    Pang, Lijuan
    Li, Feng
    BIOMARKERS IN MEDICINE, 2015, 9 (08) : 777 - 790
  • [9] Targeting ALDH1A1 and regulatory networks that support stemness in ovarian cancer cells.
    Muralikrishnan, Vaishnavi
    Nephew, Kenneth P.
    Hurley, Thomas D.
    CANCER RESEARCH, 2021, 81 (13)
  • [10] Expression of the Cancer Stem Cell Marker ALDH1A1 in Primary Breast Cancer: A Mechanism for Chemotherapy Resistance.
    Phoenix, K. N.
    Hong, X.
    Tannenbaum, S. H.
    Claffey, K. P.
    CANCER RESEARCH, 2009, 69 (24) : 582S - 582S
12345