Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways

被引:21
|
作者
Monobe, Manami [1 ]
Ema, Kaori [1 ]
Tokuda, Yoshiko [1 ]
Maeda-Yamamoto, Mari [1 ]
机构
[1] NARO, Natl Inst Vegetable & Tea Sci, Shizuoka 4288501, Japan
关键词
Pyrogallol-type polyphenols; Phagocytic activity; Caspase signaling pathways; Green tea; APOPTOSIS; RECEPTORS; IMMUNITY; TOLL;
D O I
10.1007/s10616-010-9280-2
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We investigated the phagocytosis-enhancing activity of green tea polyphenols, such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC) catechin (+C) and strictinin, using VD3-differentiated HL60 cells. EGCG, EGC, ECG and strictinin, but not EC and +C, increased the phagocytic activity of macrophage-like cells, and a caspase inhibitor significantly inhibited phagocytic activities. These results suggest that the pyrogallol-type structure in green tea polyphenols may be important for enhancement of the phagocytic activity through caspase signaling pathways.
引用
收藏
页码:201 / 203
页数:3
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