Antigenic structure of human respiratory syncytial virus fusion glycoprotein

被引：0
|
作者：
López, JA
Bustos, R
Örvell, C
Berois, M
Arbiza, J
García-Barreno, B
Melero, JA [1 ]
机构：
[1] Inst Salud Carlos III, Ctr Nacl Biol Fundamental, Madrid 28220, Spain
[2] Huddinge Hosp, Lab Clin Virol, S-14186 Huddinge, Sweden
[3] Univ Republ, Fac Ciencias, Secc Virol, Montevideo, Uruguay
来源：
JOURNAL OF VIROLOGY | 1998年 / 72卷 / 08期
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D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
New series of escape mutants of human respiratory syncytial virus were prepared with monoclonal antibodies specific for the fusion (F) protein. Sequence changes selected in the escape mutants identified two new antigenic sites (V and VI) recognized by neutralizing antibodies and a group-specific site (I) in the F1 chain of the F molecule. The new epitopes, and previously identified antigenic sites, were incorporated into a refined prediction of secondary-structure motifs to generate a detailed antigenic map of the F glycoprotein.
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页码：6922 / 6928
页数：7
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