Metal-oxo induced syn-oxidative polycyclizations of hydroxypolyenes: Biomimetic synthesis of polycyclic ether natural products

被引：17

作者：

McDonald, FE ^{[1
]}

Towne, TB ^{[1
]}

Schultz, CC ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 02期

关键词：

D O I：

10.1351/pac199870020355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development and application of syn-oxidative cyclization methodologies for the stereoselective synthesis of polyether structures corresponding to polyketide and acetogenin natural products will be described. This synthesis strategy mimics a novel but unproven proposal for the biosynthesis of, these polyether natural products. Our results with nonbiological reagents indicate that the syn-oxidative cyclization biosynthesis hypothesis is mechanistically and stereochemically viable for the chemical synthesis of polycyclic ether natural products such as monensin and goniocin.

引用

页码：355 / 358

页数：4