Epicardial perivascular adipose tissue as a therapeutic target in obesity-related coronary artery disease

被引:95
|
作者
Payne, Gregory A. [1 ]
Kohr, Meredith C. [1 ]
Tune, Johnathan D. [1 ]
机构
[1] Indiana Univ, Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA
关键词
perivascular adipose tissue; epicardial adipose tissue; endothelial dysfunction; leptin; adiponectin; adipokines; coronary artery disease; coronary circulation; inflammation; obesity; VISCERAL ABDOMINAL FAT; C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; VASCULAR FUNCTION; PERICARDIAL FAT; OXIDATIVE STRESS; PERIADVENTITIAL FAT; METABOLIC SYNDROME; GENE-EXPRESSION;
D O I
10.1111/j.1476-5381.2011.01370.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Adipose tissue is an active endocrine and paracrine organ that may influence the development of atherosclerosis and vascular disease. In the setting of obesity, adipose tissue produces a variety of inflammatory cytokines (or adipokines) that are known to modulate key mechanisms of atherogenesis. In particular, adipose tissue located on the surface of the heart surrounding large coronary arteries (i.e. epicardial perivascular adipose tissue) has been implicated in the pathogenesis of coronary artery disease. The present review outlines our current understanding of the cellular and molecular links between perivascular adipose tissue and atherosclerosis with a focus on potential mechanisms by which epicardial perivascular adipose tissue contributes to obesity-related coronary disease. The pathophysiology of perivascular adipose tissue in obesity and its influence on oxidative stress, inflammation, endothelial dysfunction and vascular reactivity is addressed. In addition, the contribution of specific epicardial perivascular adipose-derived adipokines (e.g. leptin, adiponectin) to the initiation and expansion of coronary disease is also highlighted. Finally, future investigative goals are discussed with an emphasis on indentifying novel therapeutic targets and disease markers within perivascular adipose tissue.
引用
收藏
页码:659 / 669
页数:11
相关论文
共 50 条
  • [1] Pericoronary Adipose Tissue: A Novel Therapeutic Target in Obesity-Related Coronary Atherosclerosis
    Mazurek, Tomasz
    Opolski, Grzegorz
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2015, 34 (03) : 244 - 254
  • [2] Epicardial adipose tissue in obesity-related cardiac dysfunction
    Ayton, Sarah L.
    Gulsin, Gaurav S.
    McCann, Gerry P.
    Moss, Alastair J.
    [J]. HEART, 2022, 108 (05) : 339 - +
  • [3] Epicardial Adipose Tissue-Derived Adipokines In Obesity And Coronary Artery Disease
    Karastergiou, Kalypso
    Ogston, Nicola C.
    Mohamed-Ali, Vidya
    Jahangiri, Marjan
    [J]. CIRCULATION, 2008, 118 (18) : S854 - S854
  • [4] SECRETORY PRODUCTS OF EPICARDIAL ADIPOSE TISSUE IN ASSOCIATION WITH OBESITY AND CORONARY ARTERY DISEASE
    Karastergiou, K.
    Ogston, N. C.
    Kaski, J. C.
    Mohamed-Ali, V.
    Jahangiri, M.
    [J]. HEART, 2009, 95 : A49 - A50
  • [5] IMMUNOPHENOTYPE OF STEM CELLS FROM EPICARDIAL AND PERIVASCULAR ADIPOSE TISSUE IN PATIENTS WITH CORONARY ARTERY DISEASE
    Gruzdeva, O.
    Uchasova, E.
    Dyleva, Y.
    Belik, E.
    Matveeva, V.
    Zinets, M.
    Barbarash, O.
    [J]. ATHEROSCLEROSIS, 2023, 379 : S18 - S18
  • [6] Epicardial adipose tissue and relationship with coronary artery disease
    Silaghi, Alina Cristina
    Pais, Raluca
    Valea, Ana
    Mironiuc, Aurel Ion
    Silaghi, Horatiu
    [J]. CENTRAL EUROPEAN JOURNAL OF MEDICINE, 2011, 6 (03): : 251 - 262
  • [7] Epicardial Adipose Tissue Thickness Is Related to Plaque Composition in Coronary Artery Disease
    Park, Soon Sang
    Jung, Jisung
    Mintz, Gary S. S.
    Jin, Uram
    Park, Jin-Sun
    Park, Bumhee
    Shin, Han-Bit
    Seo, Kyoung-Woo
    Yang, Hyoung-Mo
    Lim, Hong-Seok
    Choi, Byoung-Joo
    Yoon, Myeong-Ho
    Shin, Joon-Han
    Tahk, Seung-Jea
    Choi, So-Yeon
    [J]. DIAGNOSTICS, 2022, 12 (11)
  • [8] Obesity-related hypertension: Epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue
    Aghamohammadzadeh, Reza
    Heagerty, Anthony M.
    [J]. ANNALS OF MEDICINE, 2012, 44 : S74 - S84
  • [9] Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease
    Rafeh, Rim
    Viveiros, Anissa
    Oudit, Gavin Y.
    El-Yazbi, Ahmed F.
    [J]. CLINICAL SCIENCE, 2020, 134 (07) : 827 - 851
  • [10] The Associations of Epicardial Adipose Tissue With Coronary Artery Disease and Coronary Atherosclerosis
    Kim, Se-Hong
    Chung, Ju-Hye
    Kwon, Beom-June
    Song, Sang-Wook
    Choi, Whan-Seok
    [J]. INTERNATIONAL HEART JOURNAL, 2014, 55 (03) : 197 - 203