Modification of mitomycin C-induced clastogenicity by Terminalia catappa L in vitro and in vivo

被引：29
|
作者：
Liu, TY
Ho, LK
Tsai, YC
Chiang, SH
Chao, TW
Li, JH
Chi, CW
机构：
[1] NATL YANG MING UNIV,INST PHARMACOL,TAIPEI,TAIWAN
[2] BUR NATL NARCOT CONTROL CTR,TAIPEI,TAIWAN
来源：
CANCER LETTERS | 1996年 / 105卷 / 01期
关键词：
mitomycin C; micronuclei; Terminalia catappa L; hydrogen peroxide;
D O I：
10.1016/0304-3835(96)04269-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The water extract of the leaves of Terminalia catappa L. was tested for inhibition of mitomycin C-induced micronuclei in CHO-K1 cells. The simultaneous and pre-treatment of CHO-K1 cells with T. catappa extract (75 and 150 mu g/ml) significantly (P < 0.05) suppressed mitomycin C-induced micronuclei. Furthermore, gastric intubation of T. catappa extract (4.8 and 24 mg/animal per day) to male ICR mice for 8 days significantly (P < 0.01) reduced mitomycin C-induced micronuclei in peripheral blood. In addition, T. catappa dose dependently inhibited lipid peroxidation in vitro and TPA-induced hydrogen peroxide formation in human mononuclear leukocytes. The anticlastogenic effects of T. catappa in vitro and in vivo may be attributed to its antioxidative potential.
引用
收藏
页码：113 / 118
页数：6
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