Hematological and molecular analysis of β-thalassemia and Hb Lepore in Campania, Italy

被引：8

作者：

Ferrara, M ^{[1
]}

Matarese, SMR ^{[1
]}

Francese, M ^{[1
]}

Borrelli, B ^{[1
]}

Coppola, L ^{[1
]}

Coppola, A ^{[1
]}

Esposito, L ^{[1
]}

机构：

[1] Naples Second Univ, Dept Pediat, I-80138 Naples, Italy

来源：

HEMOGLOBIN | 2001年 / 25卷 / 01期

关键词：

D O I：

10.1081/HEM-100103067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This epidemiological study was based on a hematological and a molecular analysis of 310 heterozygous beta thalassemic and 75 carriers of Plb Lepore out of 3,000 microcythemic subjects from the Campania region of Italy. The molecular analysis of beta chains and the delta beta hybrid gene has shown different beta chain defects, but only the Hb Lepore-Boston-Washington type in association with haplotypes I and V. The prevalence and distribution of these molecular defects in Campania show that they are linked to historical events and to the geographical characteristics of this region.

引用

页码：29 / 34

页数：6

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