Major histocompatibility complex typing of dogs from Russia shows further dog leukocyte antigen diversity

被引：6

作者：

Kennedy, L. J. ^{[1
]}

Brown, J. J. ^{[1
]}

Barnes, A. ^{[2
]}

Ollier, W. E. R. ^{[1
]}

Knyazev, S. ^{[3
]}

机构：

[1] Univ Manchester, Ctr Integrated Genom Med Res, Manchester M13 9PT, Lancs, England

[2] Univ Liverpool, Fac Vet Sci, Liverpool L69 3BX, Merseyside, England

[3] Novosibirsk State Agr Univ, Novosibirsk, Russia

来源：

TISSUE ANTIGENS | 2008年 / 71卷 / 02期

关键词：

dog leukocyte antigen; major histocompatibility complex; Russian dog breeds;

D O I：

10.1111/j.1399-0039.2007.00965.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Blood samples from 85 Russian dogs and wolves were collected as dried blood spots on paper and transported to the UK by mail. We obtained partial or complete three-locus canine major histocompatibility complex [dog leukocyte antigen (DLA)] class II haplotypes on 81 of these samples. Six new alleles were identified: three DLA-DRB1 and three DLA-DQB1. These alleles occurred in haplotypic combinations not previously seen in other European dogs. One haplotype appeared to lack a DQB1 allele. Two of the new haplotypes segregated through a family of dogs that was investigated.

引用

页码：151 / 156

页数：6

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