Sensitive detection of nitric oxide using a 5.26 μm external cavity quantum cascade laser based QEPAS sensor

被引:10
|
作者
Tittel, Frank K. [1 ]
Dong, Lei [1 ]
Lewicki, Rafal [1 ]
Lee, George [1 ]
Peralta, Adjani [1 ]
Spagnolo, Vincenzo [2 ]
机构
[1] Rice Univ, Dept Elect & Comp Engn, 6100 S Main St, Houston, TX 77005 USA
[2] Politecn Bari, Dipartimento Interateneo Fis, I-70126 Bari, Italy
关键词
Quartz enhanced photoacoustic spectroscopy; Quantum cascade lasers; Trace gas detection; Exhaled breath analysis; Nitric oxide; Asthma and chronic pulmonary obstructive disease; ENHANCED PHOTOACOUSTIC-SPECTROSCOPY;
D O I
10.1117/12.905621
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
The development and performance of a continuous wave (CW), thermoelectrically cooled (TEC) external cavity quantum cascade laser (EC-QCL) based sensor for quantitative measurements of nitric oxide (NO) concentrations in exhaled breath will be reported. Human breath contains similar to 400 different chemical species, usually at ultra low concentration levels, which can serve as biomarkers for the identification and monitoring of human diseases or wellness states. By monitoring exhaled NO concentration levels, a fast non-invasive diagnostic method for treatment of patients with asthma and chronic obstructive pulmonary disease (COPD) is feasible. The NO concentration measurements are performed with a 2f wavelength modulation based quartz enhanced photoacoustic spectroscopy (QEPAS) technique, which is very suitable for real time breath measurements, due to the fast gas exchange inside a compact QEPAS gas cell (<5 mm(3) typical volume). In order to target the optimal interference free NO R (6.5) absorption doublet at 1900.08 cm(-1) (lambda similar to 5.263 mu m) a Daylight Solutions Inc. widely tunable, mode-hop free 100 mW EC-QCL was used. The sensor reference channel includes a 10 cm long reference cell, filled with a 0.5% NO in N-2 at 150 Torr, which is used for line-locking purpose. A minimum detection limit (1 sigma) for the EC-QCL based line locked NO sensor is similar to 5 ppbv with a 1 sec update time by a custom built control QCL compatible electronics unit.
引用
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页数:8
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