A texture-based method for classification of schizophrenia using fMRI data

This paper presents a texture-based method for classification of individuals into schizophrenia patient and healthy control groups based on their resting state functional magnetic resonance imaging (R-fMRI) data. In this research a combination of three different classifiers is proposed for classification of subjects into predefined groups. For all fMRI scans, the number of time points is reduced using principal component analysis (PCA) method, which projects data onto a new space. Then, independent component analysis (ICA) algorithm is used for estimation of the independent components (ICs). ICs are sorted based on their variance. For feature extraction a texture based operator called volume local binary patterns (VLBP) is applied on the estimated ICs. In order to obtain a set of features with large discrimination power, a two-sample t-test method is used. Finally, a test subject is classified into patient or control group using a combination of three different classifiers based on a majority vote method. The performance of the proposed method is evaluated using a leave-one-out cross validation method. Experimental results reveal that the proposed method has a very high accuracy. (C) 2014 Nalecz Institute of Biocybemetics and Biomedical Engineering. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.