Continuous flow reactors for drug discovery

被引:70
|
作者
Watts, P [1 ]
Haswell, SJ [1 ]
机构
[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England
关键词
D O I
10.1016/S1359-6446(03)02732-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
To develop a new generation of drugs, pharmaceutical companies need to be able to synthesize and screen novel chemicals with enhanced speed. New technology that would enable a cost-neutral increase in the number of potential drug candidates would provide a distinct competitive advantage. The miniaturisation of chemical reactors offers many fundamental and practical advantages of relevance to the pharmaceutical industry, which is constantly searching for controllable, information-rich, high-throughput and environmentally friendly methods of producing compounds with a high degree of chemical selectivity. This article reviews the current and future applications of micro reactors that could enhance the drug discovery process.
引用
收藏
页码:586 / 593
页数:8
相关论文
共 50 条
  • [1] Integrated Drug Discovery in Continuous Flow
    Fleming, Gabrielle S.
    Beeler, Aaron B.
    [J]. JOURNAL OF FLOW CHEMISTRY, 2017, 7 (3-4) : 124 - 128
  • [2] Continuous flow microreactors for drug discovery
    Watts, P
    [J]. CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2004, 7 (06) : 807 - 812
  • [3] Integrated Drug Discovery in Continuous Flow
    Gabrielle S. Fleming
    Aaron B. Beeler
    [J]. Journal of Flow Chemistry, 2017, 7 : 124 - 128
  • [4] Microwave and continuous flow technologies in drug discovery
    Sadler, Sara
    Moeller, Alexander R.
    Jones, Graham B.
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2012, 7 (12) : 1107 - 1128
  • [5] Micro reactors, flow reactors and continuous flow synthesis
    Watts, Paul
    Wiles, Charlotte
    [J]. JOURNAL OF CHEMICAL RESEARCH, 2012, (04) : 181 - 193
  • [6] Flow reactors for drug discovery - Flow for reaction optimization, library synthesis, and scale up
    Jones, Richard V.
    Csajagi, Csaba
    Szekelyhidi, Zsolt
    Kovacs, Ildiko
    Borcsek, Bernadett
    Urge, Laszlo
    Darvas, Ferenc
    [J]. CHIMICA OGGI-CHEMISTRY TODAY, 2008, 26 (03) : 10 - 14
  • [7] From discovery to production: Scale-out of continuous flow meso reactors
    Styring, Peter
    Parracho, Ana I. R.
    [J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2009, 5
  • [8] Biomimetic Synthesis of Drug Metabolites in Batch and Continuous-Flow Reactors
    Fodi, Tamas
    Ignacz, Gergo
    Decsi, Balazs
    Beni, Zoltan
    Turos, Gyorgy I.
    Kupai, Jozsef
    Weiser, Diana Balogh
    Greiner, Istvan
    Huszthy, Peter
    Balogh, Gyorgy T.
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2018, 24 (37) : 9385 - 9392
  • [9] Continuous flow reactors: a perspective
    Wiles, Charlotte
    Watts, Paul
    [J]. GREEN CHEMISTRY, 2012, 14 (01) : 38 - 54
  • [10] Autonomous flow reactors for discovery and invention
    Volk, Amanda A.
    Abolhasani, Milad
    [J]. TRENDS IN CHEMISTRY, 2021, 3 (07): : 519 - 522