Analysis of loss of heterozygosity in Korean patients with keratoacanthoma

被引：5
|
作者：
Ha, TW
Han, KH
Son, DG
Kim, SP
Kim, DK
机构：
[1] Keimyung Univ, Sch Med, Inst Med Genet, Dept Anat, Taegu 700712, South Korea
[2] Keimyung Univ, Sch Med, Dept Plast & Reconstruct Surg, Taegu, South Korea
[3] Keimyung Univ, Sch Med, Dept Pathol, Taegu, South Korea
来源：
JOURNAL OF KOREAN MEDICAL SCIENCE | 2005年 / 20卷 / 02期
关键词：
loss of herterozygosity; keratoacanthoma;
D O I：
10.3346/jkms.2005.20.2.340
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas have been reported. The purpose of this study was to investigate the significance of LOH in the pathogenesis of sporadic keratoacanthomas developed in 10 Korean patients. The presents of LOH at 7 microsatellite markers (D2S286, D3S1317, D5S346, D9S160 D9S171, D10S185, and D17S261) were evaluated in sporadic keratoacanthomas. LOH was found in only 1 of 10 cases at D10S185. The low frequency of LOH detected in this study suggests that LOH may not be significant in the induction of sporadic keratoacanthomas.
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页码：340 / 343
页数：4
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