Computer-aided and manual quantifications of MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss in rheumatoid arthritis of the wrist

被引:20
|
作者
Yang, Haitao [1 ,2 ]
Rivoire, Julien [2 ]
Hoppe, Michael [2 ]
Srikhum, Waraporn [2 ,3 ]
Imboden, John [4 ,5 ]
Link, Thomas M. [2 ]
Li, Xiaojuan [2 ]
机构
[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China
[2] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94107 USA
[3] Thammasat Univ, Dept Radiol, Pathum Thani, Thailand
[4] Dept Med, San Francisco, CA USA
[5] Univ Calif San Francisco, San Francisco Gen Hosp, Div Rheumatol, San Francisco, CA 94107 USA
关键词
Rheumatoid arthritis; Diagnostic imaging; Magnetic resonance imaging; RESONANCE-IMAGING QUANTIFICATION; 3 TESLA MRI; SCORING SYSTEM; RADIOGRAPHIC PROGRESSION; CONVENTIONAL RADIOGRAPHY; DISEASE-ACTIVITY; HAND SYNOVITIS; ENHANCED MRI; RA; REMISSION;
D O I
10.1007/s00256-014-2059-3
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
To investigate the reliability and validity of computer-aided automated and manual quantification as well as semiquantitative analysis for MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss of the wrist in rheumatoid arthritis (RA) compared to the OMERACT-RAMRIS. Wrist MRI was performed at 3 T in 16 patients with RA. Synovial volume and perfusion, bone marrow edema-like lesion (BMEL) volume, signal intensity and perfusion, and erosion dimensions were measured manually and using an in-house-developed automated software algorithm; findings were correlated with the OMERAC-RAMRIS gradings. In addition, a semiquantitative MRI cartilage loss score system was developed. Intraclass correlation coefficients (ICCs) were used to test the reproducibility of these quantitative and semiquantitative techniques. Spearman correlation coefficients were calculated between lesion quantifications and RAMRIS and between the MRI cartilage score and radiographic Sharp van der Heijde joint space narrowing scores. The intra- and interobserver ICCs were excellent for synovial, BMEL and erosion quantifications and cartilage loss grading (all > 0.89). The synovial volume, BMEL volume and signal intensity, and erosion dimensions were significantly correlated with the corresponding RAMRIS (r = 0.727 to 0.900, p < 0.05). Synovial perfusion parameter maximum enhancement (Emax) was significantly correlated with synovitis RAMRIS (r = 0.798). BMEL perfusion parameters were not correlated with the RAMRIS BME score. Cartilage loss gradings from MRI were significantly correlated with the Sharp joint space narrowing scores (r = 0.635, p = 0.008). The computer-aided, manual and semiquantitative methods presented in this study can be used to evaluate MRI pathologies in RA with excellent reproducibility. Significant correlations with standard RAMRIS were found in the measurements using these methods.
引用
收藏
页码:539 / 547
页数:9
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