Molecular Pathogenesis of Gastrointestinal Stromal Tumor: A Paradigm for Personalized Medicine

被引：15
|
作者：
Dermawan, Josephine K. [1 ]
Rubin, Brian P. [1 ]
机构：
[1] Cleveland Clin, Robert J Tomsich Pathol & Lab Med Inst, Cleveland, OH 44195 USA
来源：
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2022年 / 17卷
关键词：
gastrointestinal stromal tumor; driver mutations; tyrosine kinase inhibitor; personalized medicine; TYROSINE KINASE INHIBITOR; OF-FUNCTION MUTATIONS; CHRONIC MYELOGENOUS LEUKEMIA; V600E BRAF MUTATIONS; C-KIT; INTERSTITIAL-CELLS; GERMLINE MUTATION; BCR-ABL; SUCCINATE-DEHYDROGENASE; ACQUIRED-RESISTANCE;
D O I：
10.1146/annurev-pathol-042220-021510
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Over the past three to four decades, the molecular pathogenesis of gastrointestinal stromal tumors (GISTs) has been elucidated in great detail. In this review, we discuss the biological genesis of GISTs, identification of the various primary activating driver mutations (focusing on KIT and PDGFRA), oncogene addiction and targeted therapies with imatinib and other tyrosine kinase inhibitors, and the subsequent characterization of the various mechanisms of drug resistance. We illustrate how GIST has become a quintessential paradigm for personalized medicine.
引用
收藏
页码：323 / 344
页数：22
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