System biology and synthetic biology modify drug discovery and development

被引:6
|
作者
Haiech, Jacques [1 ]
Ranjeva, Raoul
Kilhoffer, Marie-Claude
机构
[1] Univ Strasbourg, Lab Innovat Therapeut, F-67401 Illkirch Graffenstaden, France
来源
M S-MEDECINE SCIENCES | 2012年 / 28卷 / 02期
关键词
HYDROCORTISONE; BIOSYNTHESIS; ARTEMISININ; YEAST;
D O I
10.1051/medsci/2012282020
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
System biology and synthetic biology modify drug discovery and development Life Sciences are built on observations. Right now, a more systemic approach allowing to integrate the different organizational levels in Biology is emerging. Such an approach uses a set of technologies and strategies allowing to build models that appear to be more and more predictive (omics, bioinformatics, integrative biology, computational biology...). Those models accelerate the rational development of new therapies avoiding an engineering based only on trials and errors. This approach both holistic and predictive radically modifies the discovery and development modalities used today in health industries. Moreover, because of the apparition of new jobs at the interface of disciplines, of private and public sectors and of life sciences and engineering sciences, this implies to rethink the training programs in both their contents and their pedagogical tools.
引用
收藏
页码:207 / 212
页数:6
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