Cytotoxic Activities of Fractions and Two Isolated Compounds from Sirih Merah (Indonesian red betel), Piper crocatum Ruiz& Pav.

被引：8
|
作者：
Emrizal [1 ]
Fernando, Armon [1 ]
Yuliandari, Riska [1 ]
Rullah, Kamal [1 ]
Indrayani, Nola Riska [1 ]
Susanty, Adriani [1 ]
Yerti, Reni [1 ]
Ahmad, Farediah [2 ]
Sirat, Hasnah M. [2 ]
Arbain, Dayar [3 ]
机构：
[1] Sekolah Tinggi Ilmu Farm Riau, Sch Pharm, Pekanbaru 28293, Riau, Indonesia
[2] Univ Teknol Malaysia, Fac Sci, Dept Chem, Skudai 81310, Johor Bahru, Malaysia
[3] Univ Andalas, Fac Pharm, Padang 25163, West Sumatra, Indonesia
来源：
INTERNATIONAL SEMINAR ON NATURAL PRODUCT MEDICINES, ISNPM 2012 | 2014年 / 13卷
关键词：
Sirih merah; Piper crocatum; Piperaceae; Indonesian red betel; Cytotoxioc;
D O I：
10.1016/j.proche.2014.12.009
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cytotoxic Cytotoxic activity investigation using brine shrimp lethality test on fractions based on polarity of solvents have been done. Inhibition concentration values of three fractions of methanolic extract of sirih merah (Indonesian red betel), Piper crocatum Ruiz and Pav., showed IC50 values of 2.04; 1.34 and 2.08 mu g/mL in n-hexane, ethyl acetate and butanol fractions, respectively. These results reveal that this plant is potential as antitumoral agent and also has a potential to be a candidate for the further investigation of cytotoxic compounds. Two isolated compounds, identified as beta-sitosterol and 2-(5', 6'-dimethoxy-3', 4'-methylenedioxyphenyl)-6-(3", 4", 5"-trimethoxyphenyl)-3,7-dioxabicyclo[3,3,0] octane have been isolated from this plant. Characterization of these compounds was carried out based on the NMR data and comparison with data from literature. (C) 2014 The Authors. Published by Elsevier B.V.
引用
收藏
页码：79 / 84
页数：6
相关论文
共 12 条
  • [1] The accumulation of two neolignan in the leaves, stems, and flower of red betel (Piper crocatum Ruiz & Pav.)
    Hartini, Y. S.
    Nugroho, L.
    [J]. INTERNATIONAL SYMPOSIUM ON BIOINFORMATICS, CHEMOMETRICS AND METABOLOMICS, 2017, 835
  • [2] INDUCTION, MULTIPLICATION, AND ACCLIMATIZATION OF RED BETEL PLANT (PIPER CROCATUM RUIZ AND PAV.) BY IN VITRO ORGANOGENESIS
    Sianipar, Nesti Fronika
    Verlina
    Rosaria
    [J]. JURNAL TEKNOLOGI, 2016, 78 (5-6): : 35 - 40
  • [3] Antioxidant Activity of Red Betel Leaves Extract (Piper crocatum Ruiz & Pav.) By Difference Concentration of Solvents
    Prayitno, Sutrisno Adi
    Kusnadi, Joni
    Murtini, Erni Sofia
    [J]. RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2016, 7 (05): : 1836 - 1843
  • [4] Virtual Screening Flavonoid Compounds from Red Betel (Piper crocatum Ruiz & Pav.) as Inhibitor of Cyclooxygenase-2 (COX-2)
    Amalia, Atikah
    Maslikah, Siti Imroatul
    Lestari, Sri Rahayu
    [J]. INTERNATIONAL CONFERENCE ON LIFE SCIENCE AND TECHNOLOGY (ICOLIST), 2020, 2231
  • [5] Preliminary Study on Fractions' Activities of Red Betel Vine (Piper crocatum Ruiz & Pav) Leaves Ethanol Extract toward Mycobacterium tuberculosis
    Rachmawaty, Farida Juliantina
    Julianto, Tatang Shabur
    Tamhid, Hady Anshory
    [J]. PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON APPLIED SCIENCES (ICAS-2), 2018, 1954
  • [6] Red Betel Apigenin Compound (Piper crocatum Ruiz & Pav.) as an Anti-inflammatory Rheumatoid Arthritis Agent through Virtual Screening
    Maslikah, Siti Imroatul
    Amalia, Atikah
    Afifah, Solichatul
    [J]. INTERNATIONAL CONFERENCE ON BIOLOGY AND APPLIED SCIENCE (ICOBAS), 2019, 2120
  • [7] Phytochemical Profile of Antibacterial Agents from Red Betel Leaf (Piper crocatum Ruiz and Pav) against Bacteria in Dental Caries
    Heliawati, Leny
    Lestari, Seftiana
    Hasanah, Uswatun
    Ajiati, Dwipa
    Kurnia, Dikdik
    [J]. MOLECULES, 2022, 27 (09):
  • [8] In vivo Immunomodulatory Effect and Histopathological Features of Mouse Liver and Kidney Treated with Neolignans Isolated from Red Betel (Piper crocatum Ruiz & Pav) Leaf
    Hartini, Yustina Sri
    Wahyuono, Subagus
    Widyarini, Sitarina
    Yuswanto, Agustinus
    [J]. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 13 (10) : 1609 - 1614
  • [9] Secondary metabolite profile in mature and old leaves of four piper species: Forest Betel ( Piper aduncum L.), Red Betel ( Piper crocatum Ruiz & Pav.), Java']Javanese Chili Betel ( Piper retrofractum Vahl.), and Green Betel ( Piper betle L.)
    Hartini, Yustina Sri
    Utaminingsih
    Julianus, Jeffry
    Patramurti, Christine
    Nugroho, Laurentius Hartanto
    [J]. PLANT SCIENCE TODAY, 2024, 11 (02): : 546 - 552
  • [10] Study on Molecular Docking of Red Betel (Piper Crocatum Ruiz & Pav.) Active Compound and Tamoxifen Drug as an Inhibitor of Estrogen Receptor-α (ER-α) that Plays a Role in Breast Cancer
    Maslikah, Siti Imroatul
    Lestari, Sri Rahayu
    Handayani, Nursasi
    Malek, Nik Ahmad Nizam Nik
    Jemon, Khairunadwa Binti
    Amalia, Atikah
    Afifah, Solichatul
    [J]. INTERNATIONAL CONFERENCE ON LIFE SCIENCE AND TECHNOLOGY (ICOLIST), 2020, 2231
12