Proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma cells to chemotherapeutic agents and overcomes chemo-resistance through inhibition of the NF-κB pathway.

被引：0
|
作者：
Ma, MH
Parker, KM
Manyak, S
Altamirano, CV
Wu, ZQ
Borad, MJ
Roussos, E
Neeser, J
Mikail, A
Frantzen, M
Adams, J
Yang, H
Siak-Shie, N
Vescio, RA
Berenson, JR
机构：
[1] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
[2] Univ Calif San Diego, La Jolla, CA 92093 USA
[3] Millennium Pharmaceut Inc, Cambridge, MA USA
来源：
BLOOD | 2001年 / 98卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1978
引用
收藏
页码：473A / 473A
页数：1
相关论文
共 14 条
  • [1] The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
    Ma, MH
    Yang, HH
    Parker, K
    Manyak, S
    Friedman, JM
    Altamirano, C
    Wu, ZQ
    Borad, MJ
    Frantzen, M
    Roussos, E
    Neeser, J
    Mikail, A
    Adams, J
    Sjak-Shie, N
    Vescio, RA
    Berenson, JR
    [J]. CLINICAL CANCER RESEARCH, 2003, 9 (03) : 1136 - 1144
  • [2] The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications
    Mitsiades, N
    Mitsiades, CS
    Richardson, PG
    Poulaki, V
    Tai, YT
    Chauhan, D
    Fanourakis, G
    Gu, XS
    Bailey, C
    Joseph, M
    Libermann, TA
    Schlossman, R
    Munshi, NC
    Hideshima, T
    Anderson, KC
    [J]. BLOOD, 2003, 101 (06) : 2377 - 2380
  • [3] The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications.
    Mitsiades, N
    Mitsiades, CS
    Richardson, PG
    Poulaki, V
    Fanourakis, G
    Tai, YT
    Chauhan, D
    Schlossman, R
    Munshi, NC
    Hideshima, T
    Anderson, KC
    [J]. BLOOD, 2002, 100 (11) : 105A - 106A
  • [4] The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    Hideshima, T
    Richardson, P
    Chauhan, D
    Palombella, VJ
    Elliott, PJ
    Adams, J
    Anderson, KC
    [J]. CANCER RESEARCH, 2001, 61 (07) : 3071 - 3076
  • [5] The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma (MM) cells.
    Hideshima, T
    Richardson, PG
    Chauhan, D
    Palombella, VJ
    Elliott, PJ
    Adams, J
    Anderson, KC
    [J]. BLOOD, 2000, 96 (11) : 461A - 461A
  • [6] Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells
    Chauhan, D
    Li, GL
    Podar, K
    Hideshima, T
    Mitsiades, C
    Schlossman, R
    Munshi, N
    Richardson, P
    Cotter, FE
    Anderson, KC
    [J]. BLOOD, 2004, 104 (08) : 2458 - 2466
  • [7] Changes in the interaction between the NF-κB and JNK pathways in multiple myeloma (MM) cells in response to PS-341 treatment.
    Ma, MH
    Yang, HH
    Chen, HM
    Yan, XM
    Kang, EL
    Berenson, J
    [J]. BLOOD, 2002, 100 (11) : 808A - 808A
  • [8] Activation of SGK1/NF- κ B pathway is correlated with low sensitivity to proteasome inhibitors in multiple myeloma Cells
    Kimura, Akihiro
    Tsubaki, Masanobu
    Takeda, Tomoya
    Matsuda, Takuya
    Takefuji, Honoka
    Nishida, Shozo
    [J]. CANCER SCIENCE, 2023, 114 : 1989 - 1989
  • [9] Proteasome Inhibitor PS-341 Effective as an anti-angiogenic agent in the treatment of human pancreatic via the inhibition of NF-κB and subsequent inhibition of vascular endothelial growth factor production.
    Harbison, MT
    Bruns, CJ
    Bold, RJ
    Elliot, JP
    Adams, J
    Abbruzzese, J
    McConkey, DJ
    [J]. CLINICAL CANCER RESEARCH, 1999, 5 : 3812S - 3812S
  • [10] Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells
    Yang, Min
    Huang, Jian
    Pan, Han-Zhang
    Jin, Jie
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2008, 22 (04) : 489 - 496
12