Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease

被引：8
|
作者：
Bronzova, J
vanDuijn, CM
Havekes, LM
deKnijff, P
Van Broeckhoven, C
Hofman, A
机构：
[1] ERASMUS UNIV ROTTERDAM, SCH MED, DEPT EPIDEMIOL & BIOSTAT, 3000 DR ROTTERDAM, NETHERLANDS
[2] ERASMUS UNIV ROTTERDAM, SCH MED, NETHERLANDS INST HLTH SCI, 3000 DR ROTTERDAM, NETHERLANDS
[3] MED UNIV SOFIA, HOSP OBSTET & GYNAECOL, LAB MOLEC PATHOL, SOFIA, BULGARIA
[4] TNO, INST PREVENT & HLTH, GAUBIUS LAB, LEIDEN, NETHERLANDS
[5] UNIV ANTWERP VIB, BORN BUNGE FDN, DEPT BIOCHEM,NEUROGENET LAB, B-2020 ANTWERP, BELGIUM
来源：
JOURNAL OF NEUROLOGY | 1996年 / 243卷 / 06期
关键词：
Alzheimer disease; apolipoprotein E gene;
D O I：
10.1007/BF00900501
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.
引用
收藏
页码：465 / 468
页数：4
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