Ag-loaded mesoporous bioactive glasses against Enterococcus faecalis biofilm in root canal of human teeth

被引:33
|
作者
Fan, Wei
Wu, Daming
Ma, Tengjiao
Fan, Bing [1 ]
机构
[1] Wuhan Univ, Sch & Hosp Stomatol, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Peoples R China
基金
中国国家自然科学基金;
关键词
Biofilm; Enterococcus faecalis; Mesoporous bioactive glass; Silver; IN-VITRO; CALCIUM HYDROXIDE; ANTIBACTERIAL PROPERTIES; ANTIMICROBIAL ACTIVITY; DENTIN; S53P4; MECHANISMS; SYSTEM; VIVO;
D O I
10.4012/dmj.2014-104
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Ag-loaded mesoporous bioactive glass (Ag-MBG) powders were synthesized and characterized. The ions release of Ag-MBGs in Tris-HCl and the pH stability of simulated body fluids after immersing Ag-MBGs were tested. Root canals were inoculated with Enterococcus faecalis for 4 weeks, and the antibacterial activity of MBGs, Ag-MBGs and calcium hydroxide against E. faecalis biofilm were evaluated. Results showed that Ag-MBGs possessed highly ordered mesoporous structure with silver nanoparticles deposited in the mesopores, which enabled a sustained Ag ions released. The biofilms treated with Ag-MBCs showed a significant structural disruption compared with MBGs. These results indicated that Ag-MBGs possess a potent antibacterial effect against E.faecolis biofilin in root canal, and the antibacterial activity was induced by the release of Ag ions from Ag-MBGs.
引用
收藏
页码:54 / 60
页数:7
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