Pulmonary Veno-occlusive Disease Following Reduced-intensity Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

被引：17

作者：

Hosokawa, Kohei ^{[1
]}

Yamazaki, Hirohito ^{[1
]}

Nishitsuji, Masaru ^{[1
]}

Kobayashi, Satoshi ^{[2
]}

Takami, Akiyoshi ^{[1
]}

Fujimura, Masaki ^{[1
]}

Nakao, Shinji ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Kanazawa, Ishikawa 9201192, Japan

[2] Kanazawa Univ, Sch Med, Dept Radiol, Kanazawa, Ishikawa 9201192, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 02期

关键词：

acute myeloid leukemia; gemtuzumab ozogamicin; pulmonary; veno-occlusive disease; reduced-intensity transplantation; STEM-CELL TRANSPLANTATION; GEMTUZUMAB OZOGAMICIN; TRICHOSPORON-ASAHII; CHILD; RISK;

D O I：

10.2169/internalmedicine.51.6302

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of pulmonary veno-occlusive disease (PVOD) following allogeneic bone marrow transplantation (BMT) for the treatment of acute myeloid leukemia (AML) from an HLA mismatched mother using a reduced-intensity conditioning (RIC) regimen including gemtuzumab ozogamicin. The patient was a 21-year-old male who complained of dyspnea with hypoxemia followed by loss of consciousness. The abnormalities in chest CT and echocardiography were compatible with a diagnosis of PVOD. Treatment with 1 mg/kg of oral prednisolone resolved dyspnea and hypoxemia within a few days, and chest CT abnormalities disappeared in a week. This report is the first to describe PVOD following RIC stem cell transplantation.

引用

页码：195 / 198

页数：4

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