The role of autophagy in Parkinson's disease

被引：15
|
作者：
Zhang, Lei [1 ]
Dong, Yaru [2 ]
Xu, Xiaoheng [1 ]
Xu, Zhong [1 ]
机构：
[1] Jilin Univ, Hosp 2, Dept Pediat, Changchun 130041, Jilin Province, Peoples R China
[2] Jilin Univ, Hosp 2, Dept Ophthalmol, Changchun 130041, Jilin Province, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 02期
基金：
中国国家自然科学基金;
关键词：
autophagy-lysosome pathway; Parkinson's disease; pathogenesis; review; CHAPERONE-MEDIATED AUTOPHAGY; ALPHA-SYNUCLEIN; CELL-DEATH; CAUSES NEURODEGENERATION; SH-SY5Y CELLS; MITOPHAGY; MUTANT; DEGRADATION; INHIBITION; NEURONS;
D O I：
10.3969/j.issn.1673-5374.2012.02.011
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation.
引用
收藏
页码：141 / 145
页数：5
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