GM food safety issues related to human health and the environment in terms of both, The purpose of the research is to establish an effective legal system in order to maximize the advantages of genetically modified foods, Reducing the negative impact of genetically modified food to humans and the environment. This article describes the US and the EU on GM food safety laws and regulation system, And analyzes China's current GM food safety system, At the same time the safety of GM foods legal regulation proposes to develop specific GM food safety regulations, Uniform implementation of genetically modified food labeling system, And the establishment of a professional team of GM food safety enforcement and other related proposals. In the healthy development of genetically modified foods, promotion from a legal perspective.