Synaptic Plasticity and Pain: Role of Ionotropic Glutamate Receptors

被引:45
|
作者
Larsson, Max [1 ,2 ,3 ]
Broman, Jonas [1 ]
机构
[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
[2] Univ Oslo, Dept Anat, Oslo, Norway
[3] Univ Oslo, Ctr Mol Biol & Neurosci, Oslo, Norway
来源
NEUROSCIENTIST | 2011年 / 17卷 / 03期
基金
瑞典研究理事会;
关键词
hyperalgesia; AMPA receptors; NMDA receptors; kainate receptors; long-term potentiation; SPINAL-DORSAL-HORN; LONG-TERM POTENTIATION; PROTEIN-KINASE-II; SUBSTANTIA-GELATINOSA NEURONS; SPINOTHALAMIC TRACT NEURONS; EVOKED FIELD POTENTIALS; PRIMARY AFFERENT NEUROTRANSMISSION; ACUTE NOXIOUS-STIMULATION; PERIPHERAL-NERVE INJURY; NEUROKININ; RECEPTOR;
D O I
10.1177/1073858409349913
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Pain hypersensitivity that develops after tissue or nerve injury is dependent both on peripheral processes in the affected tissue and on enhanced neuronal responses in the central nervous system, including the dorsal horn of the spinal cord. It has become increasingly clear that strengthening of glutamatergic sensory synapses, such as those established in the dorsal horn by nociceptive thin-caliber primary afferent fibers, is a major contributor to sensitization of neuronal responses that leads to pain hypersensitivity. Here, the authors review recent findings on the roles of ionotropic glutamate receptors in synaptic plasticity in the dorsal horn in relation to acute and persistent pain.
引用
收藏
页码:256 / 273
页数:18
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