Monodispersed polymer encapsulated superparamagnetic iron oxide nanoparticles for cell labeling

被引：30
|
作者：
Duc Nguyen [1 ]
Pham, Binh T. T. [1 ]
Vien Huynh [1 ]
Kim, Byung J. [1 ]
Pham, Nguyen T. H. [1 ]
Bickley, Stephanie A. [3 ]
Jones, Stephen K. [3 ]
Serelis, Algirdas [2 ]
Davey, Tim [2 ]
Such, Chris [2 ]
Hawkett, Brian S. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Key Ctr Polymers & Colloids, Sydney, NSW 2006, Australia
[2] DuluxGrp Australia, 1970 Princess Highway, Clayton, Vic 3168, Australia
[3] Sirtex Med Ltd, 101 Miller St, Sydney, NSW 2060, Australia
来源：
POLYMER | 2016年 / 106卷
关键词：
SPIONs; Iron oxide; Magnetic particles; Encapsulation; Polymer coating; RAFT; Control radical; Amphiphilic; Cells labeling; Monodispersed; MEDIATED EMULSION POLYMERIZATION; TARGETED DRUG-DELIVERY; MAGNETIC NANOPARTICLES; RHODAMINE-B; SURFACE; PARTICLES; NANOCOMPOSITES; TRACKING; AGENTS; PROBE;
D O I：
10.1016/j.polymer.2016.08.064
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Polymer encapsulation of raw ferrofluids was carried out by free radical emulsion polymerization using macro-RAFT copolymers as stabilizers. The iron oxide cores with positively charged surface at the pH of encapsulation were dispersed in a solution of negatively charged random macro-RAFT copolymer by ultrasonication. Uniform polymer encapsulated super paramagnetic iron oxide nanoparticles (SPIONs) were produced by feeding the mixture of methyl methacrylate (MMA) and n-butyl acrylate (BA) monomers into the dispersion containing water soluble initiator 4,4'-azobis (4-cyanopentanoic acid) (V501). Shell thickness could be controlled by adjusting the amount of coating monomer added. Polymer encapsulation of SPIONs aligned in a magnetic field produced polymer encapsulated SPION rods. Monodispersed sterically stabilized crosslinked polymer encapsulated SPIONs were synthesized using diblock and random macro-RAFT copolymers as stabilizers. Rhodamine labeled SPIONs were found to be non-cytotoxic and suitable for cell labeling. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：238 / 248
页数：11
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