Sexual dimorphism in glutathione metabolism and glutathione-dependent responses

被引：78
|
作者：
Wang, Luxi [1 ]
Ahn, Yong Joo [1 ]
Asmis, Reto [1 ]
机构：
[1] Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC 27101 USA
来源：
REDOX BIOLOGY | 2020年 / 31卷
关键词：
Macrophage; Atherosclerosis; Obesity; Redox biology; GAMMA-GLUTAMYL-TRANSFERASE; ANTIOXIDANT DEFENSE-MECHANISMS; PROTEIN S-GLUTATHIONYLATION; FEMALES LIVE LONGER; OXIDATIVE STRESS; GENDER-DIFFERENCES; GENE-EXPRESSION; MITOCHONDRIAL DYSFUNCTION; ARTERIAL STIFFNESS; ENZYME-ACTIVITIES;
D O I：
10.1016/j.redox.2019.101410
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutathione is the most abundant intracellular low molecular weight thiol in cells and tissues, and plays an essential role in numerous cellular processes, including antioxidant defenses, the regulation of protein function, protein localization and stability, DNA synthesis, gene expression, cell proliferation, and cell signaling. Sexual dimorphisms in glutathione biology, metabolism and glutathione-dependent signaling have been reported for a broad range of biological processes, spanning the human lifespan from early development to aging. Sex-depended differences with regard to glutathione and its biology have also been reported for a number of human pathologies and diseases such as neurodegeneration, cardiovascular diseases and metabolic disorders. Here we review the latest literature in this field and discuss the potential impact of these sexual dimorphisms in glutathione biology on human health and diseases.
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页数：9
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