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Poly(N-(2-hydroxypropyl)-methacrylamide)-valproic acid conjugates as block copolymer nanocarriers

被引：0
|
作者：
Alfurhood, Jawaher A. [1 ]
Sun, Hao [1 ]
Kabb, Christopher P. [1 ]
Tucker, Bryan S. [1 ]
Matthews, James H. [2 ]
Luesch, Hendrik [2 ]
Sumerlin, Brent S. [1 ]
机构：
[1] Univ Florida, George & Josephine Butler Polymer Res Lab, Ctr Macromol Sci & Engn, Dept Chem, POB 117200, Gainesville, FL 32611 USA
[2] Univ Florida, Dept Med Chem, CNPD3, Gainesville, FL 32610 USA
来源：
POLYMER CHEMISTRY | 2017年 / 8卷 / 34期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
VALPROIC ACID; HPMA COPOLYMERS; DRUG-DELIVERY; MACROMOLECULAR THERAPEUTICS; POLYMERIC NANOPARTICLES; RAFT POLYMERIZATION; IN-VIVO; DOXORUBICIN; MICELLES; INHIBITORS;
D O I：
10.1039/c7py00196g
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.
引用
收藏
页码：4983 / 4987
页数：5
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