Oxidative coupling for the spectrophotometric determination of certain cephalosporins and acetaminophen in drug formulations

被引：6
|
作者：
AlOthman, Zeid A. [1 ]
Abdalla, Mohamed A. [1 ]
机构：
[1] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2011年 / 4卷 / 02期
关键词：
Spectrophotometry; Cephalosporins determinations; Oxidative coupling; ALKALINE-DEGRADATION; PENICILLINS; SULFIDE; ASSAY;
D O I：
10.1016/j.arabjc.2010.07.014
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A spectrophotometric method for the determination of some cephalosporins and acetaminophen is described. The method is based on the hydrolysis of the cephalosporin in sodium hydroxide solution to produce the sulphide ion and the conversion of the sulphide with the p-phenylenediamine to form a violet colour. Acetaminophen is hydrolysed in sulphuric solution and the resulting p-aminophenol is oxidized with sulphide ion in the presence of iron(III) to form a red product. The method has been successfully applied to the assay of some cephalosporins and acetaminophen in drug formulations. (c) 2010 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.
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页码：239 / 242
页数：4
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