Cholesteryl ester transfer protein inhibitors: new strategies for raising high-density lipoprotein cholesterol

被引：3
|
作者：
Mabuchi, Hiroshi
Inazu, Akihiro
机构：
[1] Kanazawa Univ, Grad Sch Med Sci, Dept Lipidol, Div Med, Kanazawa, Ishikawa 920, Japan
[2] Kanazawa Univ, Grad Sch Med Sci, Dept Lab Sci, Div Hlth Sci, Kanazawa, Ishikawa 920, Japan
来源：
FUTURE LIPIDOLOGY | 2006年 / 1卷 / 04期
关键词：
cETP-inhibitor; cholesterol ester transfer protein; coronary heart disease; high-density lipoprotein cholesterol;
D O I：
10.2217/17460875.1.4.487
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epidemiological studies have shown that low-density lipoprotein cholesterol (LDL-C) is a strong risk factor for coronary heart disease (CHD), whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk for CHD. Therefore, strategies to manage dyslipidemia in an effort to prevent or treat CHID have primarily attempted to decrease LDL-C and raise HDL-C levels. Cholesteryl ester transfer protein (CETP) inhibitors have proven to be effective in achieving both a reduction in LDL-C and an increase in HDL-C. This review will discuss the current status and future prospects of CETP inhibitors in the treatment of CHID.
引用
收藏
页码：487 / 500
页数：14
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