Noscapine-Loaded Nanostructured Lipid Carriers as a Potential Topical Delivery to Bovine Mastitis Treatment

被引:0
|
作者
Otarola, Jessica J. [1 ,2 ]
Luna, Maria Alejandra [1 ,2 ]
Correa, Nestor Mariano [1 ,2 ]
Molina, Patricia G. [1 ,2 ]
机构
[1] UNRC CONICET, Inst Desarrollo Agroind & Salud IDAS, Agencia Postal 3 CP X5804BYA, Rio Cuarto, Argentina
[2] Univ Nacl Rio Cuarto, Dept Quim, Fac Ciencias Exactas Fisicoquim & Nat, Agencia Postal 3 CP X5804BYA, Rio Cuarto, Argentina
来源
CHEMISTRYSELECT | 2020年 / 5卷 / 20期
关键词
Bovine mastitis; nanostructures lipid carriers; noscapine; square wave voltammetry; topical application; ANTICANCER ACTIVITY; PROTECTIVE ROLE; IN-VITRO; NANOPARTICLES; PEROXIDATION; ANTIOXIDANTS; MELATONIN;
D O I
10.1002/slct.202001138
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Noscapine (NO) is a lipophilic benzylisoquinoline alkaloid with antioxidant, antitussive and anti-cancer properties. This study aimed to incorporate this alkaloid into an innovative topical gel-based on nanostructured lipid carrier (NLCs) to facilitate its incorporation and distribution into the organism to bovine mastitis treatment. Drug release studies were carried out using square wave voltammetry (SWV) as an alternative technique. The NLCs showed a 100 % encapsulation efficiency and, a fast release profile, releasing 86.7 % of the incorporated NO in 5 hours. On the other hand, the lipid nanoparticles ' stability was analyzed using SWV and transmission electron microscope techniques. For these studies, NLCs with and without NO incorporated were immobilized onto a carbon paste electrode and exposed to free radicals attack. The stability studies were assisted with dynamic light scattering. The results reveal a promising alternative drug delivery system for NO topical application.
引用
收藏
页码:5922 / 5927
页数:6
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