Inflammasome lights up in systemic sclerosis

被引：10
|
作者：
Henderson, John [1 ]
O'Reilly, Steven [1 ]
机构：
[1] Northumbria Univ, Fac Hlth & Life Sci, Immunol Grp, Ellison Bldg, Newcastle Upon Tyne NE2 8ST, Tyne & Wear, England
来源：
ARTHRITIS RESEARCH & THERAPY | 2017年 / 19卷
关键词：
Sclerosis; Fibrosis; Inflammasome; microRNA; Epigenetics; Interleukin-1; Caspase-1; MCC950; NLRP3; INFLAMMASOME; FIBROSIS; MIR-155;
D O I：
10.1186/s13075-017-1420-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.
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页数：2
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