β8 Integrin is Essential for Neuroblast Migration in the Rostral Migratory Stream

被引:25
|
作者
Mobley, Aaron K. [1 ]
McCarty, Joseph H. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
关键词
basement membrane; extracellular matrix; neurogenesis; cell adhesion; ADULT OLFACTORY-BULB; BLOOD-VESSELS FORM; ALPHA-V INTEGRINS; STEM-CELL NICHE; NEURONAL PRECURSORS; CHAIN-MIGRATION; VASCULAR MORPHOGENESIS; CEREBRAL-HEMORRHAGE; MAMMALIAN FOREBRAIN; ADHESION MOLECULES;
D O I
10.1002/glia.21199
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurogenesis in the post-natal brain occurs in two primary locations: the subgranular layer of the hippocampal dentate gyrus and the subventricular zone (SVZ) of the lateral ventricles. Following differentiation, neuroblasts within the SVZ migrate several millimeters to the olfactory bulbs (OBs) via a distinct anatomic route, or rostral migratory stream (RMS). The genes that govern neuroblast directional migration, and particularly those encoding cell adhesion and signaling factors, remain largely uncharacterized. Here, we report that the extracellular matrix adhesion receptor, beta 8 integrin, is essential for proper neuroblast chain formation and directional navigation in the RMS. Primary neuroblasts isolated from the mouse brain express robust levels of beta 8 integrin protein, and selective ablation of beta 8 integrin gene expression in neuroblasts leads to aberrant chain migration and size-reduced OBs. These integrin-dependent defects can be recapitulated ex vivo using isolated neurospheres or SVZ explants. Collectively, these data identify essential cell-intrinsic functions for beta 8 integrin in regulating neuroblast polarity and directional navigation in the mouse forebrain. (C) 2011 Wiley-Liss, Inc.
引用
收藏
页码:1579 / 1587
页数:9
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